21st Century - Biophysics

Aleksandra Radenovic

17/04/2024 - By 

Aleksandra Radenovic (born in 1975 in Croatia) is a Swiss and Croatian biophysicist. Her research focuses on the development of experimental tools to study single-molecule biophysics. She is a professor of biological engineering at the École Polytechnique Fédérale de Lausanne (EPFL) and head of the Laboratory of Nanoscale Biology.

Career


Radenovic studied physics at the University of Zagreb, where she wrote her Master thesis on Raman spectroscopy of Beta-Carotene[citation needed]. She then joined Giovanni Dietler’s Laboratory of Physics of Living Matter, then located at University of Lausanne, and in 2003, she graduated with a PhD on cryo atomic force microscopy.[3][4] For postdoctoral studies she went to work at University of California, Berkeley with Jan Liphardt.[5] In 2008, she became an assistant professor at EPFL where she established the Laboratory of Nanoscale Biology.[2] In 2015, she was promoted as an associate professor.[1]

Research


Radenovic’s area of research is the development of experimental techniques for the study of molecular and cell biology making use of biosensors and optical imaging. In particular, she is interested in single-molecule biophysics.[6][7]

Her research follows three main trajectories. First, she employs nanopores applied on suspended 2D material membranes, standard silicon-nitride membranes, and in glass nanocapillaries to study and manipulate single molecules.[8][9][10] Then, Radenovic studies the function of single molecules, especially protein and nucleic acid interactions, via optical tweezers, optical wrench system, anti-Brownian electrokinetic trap, and a combination of nanopores or nanocapillaries with optical tweezers.[11][12][13] Finally, based on single molecule localization microscopy, she designs super-resolution optical microscopes to extract quantitative information on single molecules.[14][15][16]

Selected publications

  • Comtet, Jean; Grosjean, Benoit; Glushkov, Evgenii; Avsar, Ahmet; Watanabe, Kenji; Taniguchi, Takashi; Vuilleumier, Rodolphe; Bocquet, Marie-Laure; Radenovic, Aleksandra (2020). “Direct observation of water-mediated single-proton transport between HBN surface defects”. Nature Nanotechnology. 15 (7): 598–604. arXiv:1906.09019. Bibcode:2020NatNa..15..598C. doi:10.1038/s41565-020-0695-4. PMID 32451503. S2CID 195316901.
  • Descloux, A.; Grußmayer, K. S.; Radenovic, A. (2019). “Parameter-free image resolution estimation based on decorrelation analysis” (PDF). Nature Methods. 16 (9): 918–924. doi:10.1038/s41592-019-0515-7. PMID 31451766. S2CID 201090412.
  • Macha, Michal; Marion, Sanjin; Nandigana, Vishal V. R.; Radenovic, Aleksandra (2019). “2D materials as an emerging platform for nanopore-based power generation”. Nature Reviews Materials. 4 (9): 588–605. Bibcode:2019NatRM…4..588M. doi:10.1038/s41578-019-0126-z. S2CID 199466502.
  • Graf, Michael; Lihter, Martina; Unuchek, Dmitrii; Sarathy, Aditya; Leburton, Jean-Pierre; Kis, Andras; Radenovic, Aleksandra (2019). “Light-Enhanced Blue Energy Generation Using MoS2 Nanopores”. Joule. 3 (6): 1549–1564. arXiv:1902.00410. doi:10.1016/j.joule.2019.04.011. S2CID 119079145.
  • Comtet, Jean; Glushkov, Evgenii; Navikas, Vytautas; Feng, Jiandong; Babenko, Vitaliy; Hofmann, Stephan; Watanabe, Kenji; Taniguchi, Takashi; Radenovic, Aleksandra (2019). “Wide-Field Spectral Super-Resolution Mapping of Optically Active Defects in Hexagonal Boron Nitride”. Nano Letters. 19 (4): 2516–2523. arXiv:1901.06989. Bibcode:2019NanoL..19.2516C. doi:10.1021/acs.nanolett.9b00178. PMID 30865468. S2CID 76661899.
  • Feng, Jiandong; Deschout, Hendrik; Caneva, Sabina; Hofmann, Stephan; Lončarić, Ivor; Lazić, Predrag; Radenovic, Aleksandra (2018). “Imaging of Optically Active Defects with Nanometer Resolution”. Nano Letters. 18 (3): 1739–1744. arXiv:1706.06313. Bibcode:2018NanoL..18.1739F. doi:10.1021/acs.nanolett.7b04819. PMID 29393651. S2CID 46883656.
  • Feng, Jiandong; Liu, Ke; Graf, Michael; Dumcenco, Dumitru; Kis, Andras; Di Ventra, Massimiliano; Radenovic, Aleksandra (2016). “Observation of ionic Coulomb blockade in nanopores” (PDF). Nature Materials. 15 (8): 850–855. Bibcode:2016NatMa..15..850F. doi:10.1038/nmat4607. PMID 27019385.
  • Feng, Jiandong; Graf, Michael; Liu, Ke; Ovchinnikov, Dmitry; Dumcenco, Dumitru; Heiranian, Mohammad; Nandigana, Vishal; Aluru, Narayana R.; Kis, Andras; Radenovic, Aleksandra (2016). “Single-layer MoS2 nanopores as nanopower generators” (PDF). Nature. 536 (7615): 197–200. Bibcode:2016Natur.536..197F. doi:10.1038/nature18593. PMID 27409806. S2CID 4447903.
  • Feng, Jiandong; Liu, Ke; Bulushev, Roman D.; Khlybov, Sergey; Dumcenco, Dumitru; Kis, Andras; Radenovic, Aleksandra (2015). “Identification of single nucleotides in MoS2 nanopores”. Nature Nanotechnology. 10 (12): 1070–1076. arXiv:1505.01608. Bibcode:2015NatNa..10.1070F. doi:10.1038/nnano.2015.219. PMID 26389660. S2CID 8087282.
  • Traversi, F.; Raillon, C.; Benameur, S. M.; Liu, K.; Khlybov, S.; Tosun, M.; Krasnozhon, D.; Kis, A.; Radenovic, A. (2013). “Detecting the translocation of DNA through a nanopore using graphene nanoribbons” (PDF). Nature Nanotechnology. 8 (12): 939–945. Bibcode:2013NatNa…8..939T. doi:10.1038/nnano.2013.240. PMID 24240429.

References

  1. ^ Jump up to:a b “23 professors appointed at ETH Zurich and EPFL | ETH-Board”. www.ethrat.ch. Retrieved 22 September 2020.
  2. ^ Jump up to:a b “Group members”. www.epfl.ch. Retrieved 22 September 2020.
  3. ^ Radenovic, Aleksandra (2003). Development of low temperature atomic force microscope for biological applications (Thesis). OCLC 85233283. Retrieved 6 June 2022.
  4. ^ Libioulle, Laurent; Radenovic, Alexandra; Bystrenova, Eva; Dietler, Giovanni (24 January 2003). “Low noise current-to-voltage converter and vibration damping system for a low-temperature ultrahigh vacuum scanning tunneling microscope”. Review of Scientific Instruments. 74 (2): 1016–1021. Bibcode:2003RScI…74.1016L. doi:10.1063/1.1533100. ISSN 0034-6748.
  5. ^ “Liphardt Lab”. liphardtlab.stanford.edu. Retrieved 22 September 2020.
  6. ^ “Aleksandra Radenovic”. EPFL Online People Directory.
  7. ^ “Research Topics”. www.epfl.ch. Retrieved 23 September 2020.
  8. ^ Feng, Jiandong; Graf, Michael; Liu, Ke; Ovchinnikov, Dmitry; Dumcenco, Dumitru; Heiranian, Mohammad; Nandigana, Vishal; Aluru, Narayana R.; Kis, Andras; Radenovic, Aleksandra (11 August 2016). “Single-layer MoS2 nanopores as nanopower generators”. Nature. 536 (7615): 197–200. Bibcode:2016Natur.536..197F. doi:10.1038/nature18593. ISSN 0028-0836. PMID 27409806. S2CID 4447903.
  9. ^ Liu, Ke; Feng, Jiandong; Kis, Andras; Radenovic, Aleksandra (25 March 2014). “Atomically Thin Molybdenum Disulfide Nanopores with High Sensitivity for DNA Translocation”. ACS Nano. 8 (3): 2504–2511. doi:10.1021/nn406102h. ISSN 1936-0851. PMID 24547924.
  10. ^ Macha, Michal; Marion, Sanjin; Nandigana, Vishal V. R.; Radenovic, Aleksandra (30 July 2019). “2D materials as an emerging platform for nanopore-based power generation”. Nature Reviews Materials. 4 (9): 588–605. Bibcode:2019NatRM…4..588M. doi:10.1038/s41578-019-0126-z. ISSN 2058-8437. S2CID 199466502.
  11. ^ Feng, Jiandong; Liu, Ke; Bulushev, Roman D.; Khlybov, Sergey; Dumcenco, Dumitru; Kis, Andras; Radenovic, Aleksandra (21 September 2015). “Identification of single nucleotides in MoS2 nanopores”. Nature Nanotechnology. 10 (12): 1070–1076. arXiv:1505.01608. Bibcode:2015NatNa..10.1070F. doi:10.1038/nnano.2015.219. ISSN 1748-3387. PMID 26389660. S2CID 8087282.
  12. ^ Kayci, Metin; Radenovic, Aleksandra (12 November 2015). “Single florescent [sic] nanodiamond in a three dimensional ABEL trap”. Scientific Reports. 5 (1): 16669. Bibcode:2015NatSR…516669K. doi:10.1038/srep16669. ISSN 2045-2322. PMC 4642320. PMID 26559890.
  13. ^ “Full Page Reload”. IEEE Spectrum: Technology, Engineering, and Science News. Retrieved 23 September 2020.
  14. ^ Feng, Jiandong; Liu, Ke; Graf, Michael; Dumcenco, Dumitru; Kis, Andras; Di Ventra, Massimiliano; Radenovic, Aleksandra (28 March 2016). “Observation of ionic Coulomb blockade in nanopores”. Nature Materials. 15 (8): 850–855. Bibcode:2016NatMa..15..850F. doi:10.1038/nmat4607. ISSN 1476-1122. PMID 27019385.
  15. ^ Comtet, Jean; Grosjean, Benoit; Glushkov, Evgenii; Avsar, Ahmet; Watanabe, Kenji; Taniguchi, Takashi; Vuilleumier, Rodolphe; Bocquet, Marie-Laure; Radenovic, Aleksandra (25 May 2020). “Direct observation of water-mediated single-proton transport between hBN surface defects”. Nature Nanotechnology. 15 (7): 598–604. arXiv:1906.09019. Bibcode:2020NatNa..15..598C. doi:10.1038/s41565-020-0695-4. ISSN 1748-3387. PMID 32451503. S2CID 195316901.
  16. ^ “StackPath”. www.laserfocusworld.com. Retrieved 23 September 2020.

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